pipeline update, page-26

A new short paper of interest (to me) amongst all of the tweets.

Midkine, a middle manager of ß2 integrins

by M. Herter and Tanya N. Mayadas

the authors are getting to the heart of midkine's signalling / inflammation role which mobilises certain white blood cell cells (neutrophils)to the site of a trauma.

The authors conclude:

"In summary, Weckbach et al have provided
a molecular mechanism for the observed
requirement for MK in leukocyte extravasation
in many in?ammation models. The speci?c
function of MK for a discrete process in
leukocyte recruitment and its extracellular
accessibility make it an IDEAL TARGET FOR PHARMACOLOGIC INTERVENTION." [my capitalisations]

This is coming from Harvard Medical School and the authors declare not conflict of interest.

cheers