i think its time, page-5

I do not know if there is a official total length or cumulative dosage restriction and I guess it would depend on how the patients body is reacting. For the trial we are conducting remission would be very very unusual. Patients that are still able to accept treatment without toxic or other side affects I assume it would continue at oncologists and patients discretion with dose modifications to combat reactions. treatment. Normally in cancer treatment they have a scale of toxicity and reactions and use it to determine treatment holidays and dosage alternatives and it is all done per individual.

From my notes years ago

Most common side affects
Rash
Nausea, vomiting
Fatigue
Abdominal pain
? Mg
Anorexia
Diarrhea (may be severe)
Fever
Mucositis
Myelosuppression ± infection,
bleeding (may be severe)
Cough, dyspnea

Less Common Side Effects, but maybe
Severe or LifeThreatening

Hemorrhage
Hypersensitivity
I obstruction
GI perforation
Cardiotoxicity
Hemolytic uremic syndrome
Pancreatitis
Pneumonitis
Venous and arterial
thromboembolism
Handfoot
syndrome (may be
severe)



From Uk site - 6 months is 13 cycles of 2 weeks and 18 cycles is a bit over 8 months.

"You usually have this chemotherapy as cycles of treatment. Each cycle of treatment lasts 2 weeks. Depending on your needs, you may have up to 12 cycles, taking up to 6 months in total."
http://www.cancerresearchuk.org/cancer-help/about-cancer/treatment/cancer-drugs/folfiri


A quite up to date article I had not read before today.

http://www.uptodate.com/contents/colorectal-cancer-treatment-metastatic-cancer-beyond-the-basics