I have mentioned Cold Spring Harbor Labs several times in the past and why I think a partnership/joint venture with them would be good for ddRNAi, well CSHL has now ventured out into in silico shrna technology. Their extensive shrna libraries and shrna modelling software should make substantial reductions in the time necessary for drug discovery in the field of ddRNAi - just look how long it has taken us to work out which HBV gene to target.
http://www.eurekalert.org/pub_releases/2014-12/cshl-ctf120514.php?
http://www.sciencedirect.com/science/article/pii/S1097276514008351
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