Published paper re phylomer peptides

For some reason which my tired brain can't figure out, this will only type in italics, bold or underlined. I figured that italics shouted less!


Phylomer peptides as target validation tools for Cryptosporidium are the focus of a newly published study in Experimental Parasitology (January 2015). The study was funded by Phylogica and the ARC Linkage Grant. Research was conducted by the School of Veterinary and Life Sciences, Murdoch University; Phylogica, Telethon Institute for Child Health Research and the School of Population Health, University of Queensland.

The Phylomer screening approach used in the study was reported to have yielded a relatively high functional hit rate. The authors also reported successful validation of the concept that cell penetrating motifs such as TAT can be used to deliver therapeutic Phylomer cargoes inside cells.

The authors note in conclusion
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Phylomers have enormous potential as target validation tools for Cryptosporidium and other organisms and diseases because they are able to bind with high affinity to target proteins and disrupt function.”




Cryptosporidium is the most common non-viral cause of diarrhoea worldwide. It most severely impacts young children and the immunocompromised but is also a problem in the livestock and poultry industries. The small-sized parasite is resistant to most known disinfectants and current treatment options are limited.


http://www.sciencedirect.com/science/article/pii/S001448941400246X


http://researchrepository.murdoch.edu.au/24790/1/inosine_monophosphate_dehydrogenase_gene.pdf