why are you all so convinced?, page-9

shRNA libraries exist in much the same way as siRNA libraries do. They are just about on equal footing.

DECIPHER libraries are barcoded lentiviral shRNA libraries optimized for RNAi Genetic Screens in pooled format. They are made to cover nearly the entire annotated human gene set and most annotated mouse gene set. Lentiviral shRNA libraries were chosen over synthetic siRNA collections for their advantages in cancer research, specifically for the ability to efficiently transduce a range of cell types, including non-dividing cells, and for the highly effective long-term gene silencing. The pooled format screens follow a simple protocol and do not require access to expensive high-throughput arrayed screen equipment and infrastructure, putting large-scale pooled shRNA knockdown screens within reach of any researcher.

Hundreds of research projects are underway using shRNA again a multitude of diseases.