More serious issues than the name change, page-64

“...if that evidence existed we would be at 3c? So without phase 3 results know one can make a judgement on potential?”

Its an interesting way of looking at it GC. I think the idea is that everything builds from the ground up.

With a product having to pass increasingly difficult tests during its development. And your confidence is based n how easily it cleared those earlier tests.

But for POH I think the problem has been they are so slow those goal-posts have shifted over time. And its not until recently that it has become clearer what exactly is required. How high is the bar.

The lack of papers seem to me to be a symptom. Papers report science experiments . We tried this, it may or may not have worked, but guess what it did. And it wasn’t due to chance (p<0.05).

Null hypothesis testing is all about binary outcomes.

But binary outcomes have been an anathema to Rosen and Ogru. After some spectacular crashes with the obesity drug in the early days (Ogru) and then jointly with Nestle.

The consequence of avoiding binary outcomes is no papers.

POH became like the student that chooses continuously assessed subjects to avoid exams. And handed up pretty share holder pr updates for assessment for years and kind of passed.

But a few months ago POH met with the exam kings of the world – the FDA. Binary outcome central.

POH report that more trials are required, they are challenging and not without risk. Yep ... well hello ... thats what exams are like.

Is the student up to it? Well the market halved the share price.

I have a half a notion the new Board is less about getting the old to work and more about working out what the new will be.

The answer to this doesn’t just fall out of the sky – the technology needs clever matching to a problem. Which is a very different way of looking at the technology as a solution in search of a problem.

So its not steady as she goes. Hire a CRO, negotiate a contract, sit back and wait for the results of the US P2 oxym to roll in.

My guess is the systemic oxym patch will get the chop, and never make it to the IND starting gate. The clever guys on the new Board will conjure up some new ideas and with money in bank away it all goes again.

But we shall see.