Studies from Sirtex Medical Ltd. Reveal New Findings on Blood Cells

Some good news on the nano particles. Steve Jones has been working on some of this stuff for years - I hope it comes to something. All still very early, but an indication for the R&D that is progressing.

He got published in the International Journal of Nanomedicine - kudos for Steve!! A peer reviewed Journal, considered about as good as one can get in research.

'An international, peer-reviewed journal focusing on the application of nanotechnology in diagnostics, therapeutics, and drug delivery systems throughout the biomedical field. Reflecting the growing activity in this emerging specialty, the aim of this journal is to highlight research and development leading to potential clinical applications in the prevention and treatment of disease.'
-----------------------------------------------------------------------------

http://www.4-traders.com/SIRTEX-MED...dings-on-Blood-Cells-The-interactio-21399205/

Sirtex Medical : Studies from Sirtex Medical Ltd. Reveal New Findings on Blood Cells (The interaction of sterically stabilized magnetic nanoparticles with fresh human...​

	Column 1	Column 2	Column 3	Column 4	Column 5	Column 6
0

11/12/2015 | 03:00pm US/Eastern​

Studies from Sirtex Medical Ltd. Reveal New Findings on Blood Cells (The interaction of sterically stabilized magnetic nanoparticles with fresh human red blood cells)
By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Blood Cells is now available. According to news reporting originating from Sydney, Australia, by NewsRx correspondents, research stated, "Sterically stabilized superparamagnetic iron oxide nanoparticles (SPIONs) were incubated with fresh human erythrocytes (red blood cells [RBCs]) to explore their potential application as magnetic resonance imaging contrast agents. The chemical shift and linewidth of Cs-133(+) resonances from inside and outside the RBCs in Cs-133 nuclear magnetic resonance spectra were monitored as a function of time."
Our news editors obtained a quote from the research from Sirtex Medical Ltd., "Thus, we investigated whether SPIONs of two different core sizes and with three different types of polymeric stabilizers entered metabolically active RBCs, consuming glucose at 37 degrees C. The SPIONs broadened the extracellular Cs-133(+) nuclear magnetic resonance, and brought about a small change in its chemical shift to a higher frequency; while the intracellular resonance remained unchanged in both amplitude and chemical shift. This situation pertained over incubation times of up to 90 minutes. If the SPIONs had entered the RBCs, the intracellular resonance would have become broader and possibly even shifted. Therefore, we concluded that our SPIONs did not enter the RBCs. In addition, the T-2 relaxivity of the small and large particles was 368 and 953 mM(-1) s(-1), respectively (three and nine times that of the most effective commercially available samples)."
According to the news editors, the research concluded: "This suggests that these new SPIONs will provide a superior performance to any others reported thus far as magnetic resonance imaging contrast agents."
For more information on this research see: The interaction of sterically stabilized magnetic nanoparticles with fresh human red blood cells. International Journal of Nanomedicine, 2015;10():6645-6655. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Blood Cells).
The news editors report that additional information may be obtained by contacting B.T.T. Pham, Sirtex Med Ltd, Sydney, NSW, Australia. Additional authors for this research include N. Jain, P.W. Kuchel, B.E. Chapman, S.A. Bickley, S.K. Jones and B.S. Hawkett.​