mode of action

Coramsines unique mode of action could possibly give it the edge over chemos in some cancers. Most chemos need the cell to divide before they can kill it. Coramsine gains immediate entry to the cancer cell through their patented Rhamnose Binding Protein, found on many cancer cells,to kill the cell,thereby maybe gaining further advantage over traditional chemos in slow growing cancers.
"A multi institutional rapid autopsy program in PC found that it may be different from other cancers: “These data also have implications for developing therapy because treatment based on using agents that act on cells with a rapid doubling time may not be effective in androgen-independent prostate cancer. The low rate of effectiveness of traditional chemotherapy agents in prostate cancer appears to reflect this finding.” “ In conclusion, it is of note that no single biomarker or group of biomarkers has yet been identified that can successfully predict disease recurrence 100% of the time. Although studies have tried to identify subsets of genes that characterize the metastatic phenotype, these, by definition, ignore the heterogeneity of metastatic cancer. We demonstrate that end-stage hormone-refractory metastatic prostate cancer is a heterogeneous group of diseases.” Androgen-Independent Prostate Cancer Is a Heterogeneous Group of Diseases Lessons from a Rapid Autopsy Program Cancer Research 64, 9209-9216, " December 15, 2004 http://cancerres.aacrjournals.org/cgi/content/full/64/24/9209