It has been well documented that Coramsine down regulates the cytokyne interlukin6. IL6 is responsible swelling and feeling bad among other things. Coramsine is being considered as a palative treatment for this reason I think. A huge market. Researchers at MLNM(Nasdaq)found an interesting result of IL6 reduction some time back. This could open up all sorts of interesting prospects for Coramsine. > > >Abstract > > > > > >The ubiquitin-conjugating enzyme CDC34 (UBC3) is linked to cell cycle > > >progression in diverse cell types; however, its role in multiple myeloma > > >(MM) pathogenesis is unclear. Here, we show that CDC34 is highly expressed > > >in patient MM cells and MM cell lines versus normal cells. Blocking CDC34 > > >using a dominant-negative strategy enhances the anti-MM activity of > > >Bortezomib/Proteasome inhibitor PS-341, dexamethasone (Dex) and > > >2-Methoxyestradiol (2ME2). The expression of wild-type CDC34 reduces > > >Dex-induced cytotoxicity in MM cells. Moreover, inhibition of CDC34 > > >enzymatic activity abrogates interleukin-6-induced protection against > > >Dex-induced apoptosis. Together, these findings provide evidence that (1) > > >CDC34 expression is associated with growth and survival of MM > cells and (2) > > >blocking CDC34 activity not only enhances anti-MM activity of Bortezomib > > >and 2ME2 but also overcomes IL-6-triggered Dex-resistance. > > > Assay tests in the US have indicated Coramsine can improve the performance of some chemos. Good luck to Solbec holders.
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