The current study has shown that treatment with the combined adjuvant of poly(I:C) plus LAG-3-Ig profoundly enhances antitumor responses induced by tumor peptide vaccine and leads to complete regression of pre-established tumor in association with long-term immunological memory. Furthermore, mechanistic analyses revealed the activation of Th1-type responses and prevention of the exhausted phenotype in tumor-specific T cells by this treatment. To the best of our knowledge, our study is the first to report a great advantage in combining adjuvants poly(I:C) and LAG-3-Ig for therapeutic cancer vaccinerom
From the discussion section of the Japanese paper.....Last sentence is interesting....
What next?, page-55
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