Profit margins on orphan drugs can be as high as 80% (compared to pharmaceutical average of around 16%).
http://www.tandfonline.com/doi/full/10.1517/21678707.2013.752128#.Vxg9GEx95hE
http://www.raredr.com/news/Risks-Rewards-Developing-Orphan-Drugs
Ann: Annual Report to shareholders-NEU.AX, page-42
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