Groundbreaking new work by Rudy Tanzi CSA, page-31

Yet another lie "ps Oliveri and Vecchio never heard of PBT2 and the "pipeline" so don't expect any cash." Note authors below with specific reference to PBT2. Also note reference to anti-cancer properties of PBT2.

European Journal of Medicinal Chemistry
Volume 120, 14 September 2016, Pages 252–274

Review article

8-Hydroxyquinolines in medicinal chemistry: A structural perspective

• Valentina Oliveri^{a, b, ,} ,
• Graziella Vecchio^{a, b}

Highlights


•The interest in 8-hydroxyquinolines has grown exponentially.
•8-hydroxyquinoline is an important scaffold in drug design and discovery.
•Biological activity of 8-hydroxyquinoline-based systems is reported.
•The interaction of 8-hydroxyquinolines with essential metal ions is described.
•Postulated mechanisms of action of 8-hydroxyquinoline-based systems are discussed.

Abstract

8-Hydroxyquinolines are heterocyclic compounds characterized by a moderate metal-binding affinity. The interest in 8-hydroxyquinolines has grown exponentially in the last two decades as they are privileged structures for the design of new drug candidates that exert a host of biological effects on various targets.
The study of biological activities such as neuroprotection, anticancer, antibacterial, antifungal activity has been further promoted by the synthetic versatility of 8-hydroxyquinoline, which allows the generation of a large number of derivatives. These include numerous multifunctional analogues having the metal-binding motif of 8-hydroxyquinoline. In this review, we have summarized 8-hydroxyquinolines, 8-hydroxyquinoline-like compounds, 8-hydroxyquinoline-loaded nanoparticle systems with respect to their biological activities, interaction with metal ions and mechanisms of action.


Keywords

Clioquinol;Nanoparticle;PBT2;Nitroxoline;Metal complexes;Alzheimer;Glycoconjugate; Anticancer