Panno speaks on recent changes, page-29

I agree, this form of shrna where he loop in the rna requires the use of the clever enzyme, which means it is slow acting this is y viral load data has to be compiled over a longer period of time to see reduction this is simple science at this point. That's the real proble with the drug it works so slowly now if they took he gradalis approach and used a kinked shrna in combination with the loop the data would be out, I've made this point before. I'll up load the paper on the different types of shrna on a few mins