Hi all,
please educate me if I'm wrong, however my understanding as far as the HSV-2 trail goes that because of the delay in vetting suitable candidates it is in effect two groups of 20 NOT a group of 40 and therefore 2 groups of 6 months, as such if the protocols are not changed for the second group it would be improbable that a superior result be obtained in the second group. So if 58% was achieved again it would in fact validate the first half of the trail in a positive manner. Talking to JC earlier in FEB he indicated that dosage frequency/amounts would be changed as part of the trails going forward but didn't indicate if would be adjusted for the second 20 participants of HSV-2. Lastly he also talked about duration and as has been stated here that the longer you on it the better the effect so after say 9 months a greater result would be achieved. So if the first 20 continued to be boosted sure a higher value would be achieved however my understanding is that both groups will be treated the same and in effect that means 2 6month trails conducted in the same manner with hopefully the same number 58%.
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