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Research: Endog. Pleiotropin and Midkine Regulate LPS-induced Glial Responses

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mightypirate

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29/12/17

00:26

Post #: 29920748
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Endogenous pleiotrophin and midkine regulate LPS-induced glial responses

This is from a research article in
Neuroscience Letters
Volume 662, 1 January 2018, Pages 213-218

https://www.sciencedirect.com/science/article/pii/S0304394017308649

Conclusion
Our findings show for the first time that endogenous PTN and MK modulate the astrocytic response induced by LPS. The data suggest that PTN and/or MK may be involved in the modulation of LPS-induced microglial activation but further studies are needed to delineate their importance.

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Highlights
• LPS-induced glial responses were tested in PTN-/- and MK-/- mice.

• Endogenous expression of PTN and MK in vivo is required for LPS-induced astrogliosis.

• The data suggest that PTN and MK may modulate LPS-induced microglial activation.

• Regulation of glial responses to LPS depends on the expression levels of PTN and MK

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Side note one.
Cellmid has a brain cancer program.
http://www.cellmid.com.au/SiteMedia...dkine antibodies show anti-tumor activity.pdf

Side note two.

Astrogliosis
Astrogliosis is a pathological hallmark of conditions such as epilepsy, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis.

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(Source)

CDY Price at posting: 48.5¢ Sentiment: Buy Disclosure: Held
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