Nice one Roka. The number of subjects is pretty easy to calculate for a given statistical power when you set the beta you are after. BNO would have had plenty of advice on this and they have needed up with a reasonably small number (at 193). And the three measures that may reach significance of p < 0.05 are the ones where they are likely to get a measure across the entire study group (hence the 3 they chose). It is not unusual to load in other secondary objectives.
The value driver from the primary objective, if there is a significant result, is that they can then justify a PhIIb, if BNO wants to do that, and launch into conversations with a bigger partner to fund a PhIII. And both can occur simultaneously. GLTA
BNO Price at posting:
59.0¢ Sentiment: Buy Disclosure: Held
