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    Prana reports positive results for PBT2
    11:40, Tuesday, 26 February 2008

    Sydney - Tuesday - February 26: (RWE Aust Business News) - Prana
    Biotechnology Ltd (ASX:PBT) has announced that PBT2 has demonstrated
    safety and tolerability and reduced Abeta 42, in a Phase IIa study of
    PBT2 in patients with early Alzheimer's Disease.
    PBT2 also improved executive function performance in select
    cognitive tests.
    In this double blind multi-centre clinical trial, 78 patients in
    Sweden and Australia were randomised to receive either a placebo, PBT2
    50mg or PBT2 250mg capsule once per day for 12 weeks.
    Analysis of the trial data demonstrated that the safety and
    tolerability profile of PBT2 at both doses was indistinguishable from
    that of placebo. There were no study withdrawals related to adverse
    events and there was no serious adverse event in any PBT2 treated
    patient.
    "This is a very exciting and important milestone for the company,
    particularly because PBT2, a drug known to inhibit the toxic oligomers of
    Abeta that cause the functional damage in Alzheimer's Disease, was able
    to show such a clear effect in a short trial," said Geoffrey Kempler,
    Prana's chairman and CEO.

 
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