We at the early days of the MSC revolution.
I've been in MSB before. I think its a great buggy manufacturer making great cars.
CYP is making cars, the Henry Ford way. Consistent and able to do so at much larger scale.
Bazsa is like the early car buyers. Why would you make a car that way? what about the hand built craftmanship? What do you mean its not individually tailored to me? You mean the same car is much the same quality from one to the next? What, you can supply the dealer with 50 in a week, that used to take my buggy guy 6 months to fulfil. Hold on, its also a fifth of the cost and I can actually afford that where the other one will send me broke in short order.
GVHD is a proof point for a different method. Best way to prove a new method is to create the same thing using the new method and compare it to the old one. The GVHD condition itself is not the main objective. CYP is proving the method produces better results, that a better product for this condition may drop out of the process as well is a bonus. But if it doesnt, it doesnt matter, the trial mattered and everything that follows can use that result. Add Phase 2 acceptance in Japan as sufficient in some cases and you have a significant advantage. e
Since the MSCs are pretty much 100% consistent with no large variance between batches. Successful Phase 1 applies to all follow on products, since its the same root IPSC stock and single donor process.
CYP are confident in supplying quality product for the NHMRC trial in the hundreds of people scale. For a trial. Ask yourself whether that is something current MSC therapeutic providers would generally be willing to sign up to.
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