research reports and media, page-57

Hmm not sure if those nasty side effects posted properly: here they are in hopefully a more readable format:

Since the product was first introduced, thefollowing have been reported in patients using ENBREL:

* Serious Infections

- Many occurred in people prone to infection, such as those with

advanced or poorly controlled diabetes

- Some serious infections were fatal

- Rare cases of tuberculosis

* What to do/Not do

- Do not start ENBREL if you have an infection or are allergic to

ENBREL or its components

- Tell your doctor if you are prone to infection

- Stop ENBREL if a serious infection occurs

- Contact your doctor if you have questions about ENBREL or develop

an infection

* Serious nervous system disorders such as multiple sclerosis, seizures,

or inflammation of the nerves of the eyes.

- Tell your doctor if you have ever had any of these disorders or if

you develop them after starting ENBREL.

* Rare reports of serious blood disorders (some fatal)

- Contact your doctor immediately if you develop symptoms such as

persistent fever, bruising, bleeding, or paleness

* In medical studies of all TNF-inhibitors, a higher rate of lymphoma (a

type of cancer) was seen compared to the general population, however,

the risk of lymphoma may be up to several fold higher in RA patients.

The role of TNF-inhibitors in the development of lymphoma is unknown.

* The incidence of other cancers has not increased with extended

exposure to ENBREL and is similar to the expected rate.

* ENBREL can also cause injection site reactions.

* In a medical study of patients with JRA, infections, headaches,

abdominal pain, vomiting, and nausea occurred more frequently than in

adults.

- The kinds of infections reported were generally mild and similar to

those usually seen in children

- Other serious adverse reactions were reported rarely, including

serious infections (2 percent) and depression/personality disorder

(1 percent)