Nature: Circular ecDNA promotes high oncogene expression, page-3

Extrachromosomal circular DNAs: an extra piece of evidence to depict tumor heterogeneity
Ishita Tandon, Roshni Pal, Jayanta K Pal & Nilesh K Sharma
Published Online:31 May 2019
https://doi.org/10.2144/fsoa-2019-0024

”The observed differences between normal and cancer cells in terms of extent and nature of eccDNAs (2–20 kbp) and eccDNAs in the form of microDNAs (100–400 bp) are suggested to serve as biomarkers in cancer research [1–4]. These eccDNAs and microDNAs are shown to be released as extracellular free DNAs in the tumor. These can then serve as a basis for detection, monitoring of tumor responses to drug treatment and survival [35–40]. It is also proposed as the early biomarkers in certain tumor types detected as extracellular free eccDNAs in tumor tissues and other biological fluids of cancer patients [35–40].”

https://www.future-science.com/doi/10.2144/fsoa-2019-0024