http://www.sujuanba.org/blog/bayer-s-regorafenib-is-the-first-drug-to-enter-gbm-agile
Story here re the German giant Bayer very happy to be selected and take part in Agile GBM. …."more accurate and faster" - "more efficient approach to testing new treatments" UCLA Professor
The Bayer drug could be a candidate to work in combination with GDC 0084. (my words)
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GBM AGILE is an international, innovative platform trial designed to more rapidly identify effective therapies for patients with glioblastoma through response adaptive randomization and a seamless phase 2/3 design. The trial will be conducted under a master protocol, allowing multiple therapies or combinations of therapies from different pharmaceutical partners to be evaluated simultaneously. Experimental treatments will be added to or dropped from the trial over time. The trial design and infrastructure constitutes a more efficient approach to testing new therapies for GBM, thus bringing new potentially beneficial treatments to patients sooner. “GBM AGILE is an important step forward for glioblastoma and our patients who desperately need new options. As a more accurate and faster way to evaluate new interventions, we hope to ease the burden of development in glioblastoma and invite more activity in the space,” according to Dr. Timothy Cloughesy, the Principal Investigator of GBM AGILE trial, as well as a UCLA professor of clinical neurology.
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