Upgraded from Firefox 2... it ate about 2/3 of my bookmarks (apparently a new bookmarking system which doesn't work)
Also major hard drive thrashing. Every 2 mins or so my hard drive goes flat out and Firefox 3 freezes. I managed to search forums for some software tweaks to help the problem.
These bugs are all over the net, its not just me. I suggest people avoid Firefox 3 until they iron these issues out.