Takeda-Turnstone Deal, page-2

https://www.fiercebiotech.com/research/cancer-killing-virus-boosts-immuno-oncology-responses-mice-astellas-led-study

Also out of Japan, Astellas Pharma's drug discovery unit:

"The researchers engineered a piece of the vaccinia virus, which is part of the poxvirus family, so it can deliver two cytokines that stimulate anti-cancer responses from immune cells: interleukin-7 (IL-7) and IL-12. When they injected the virus directly into tumors in mice, the cancers regressed, they reported in the journal Science Translational Medicine. Combining the virus with anti-PD-1 or anti-CTLA-4 antibodies was even more effective."

"The researchers observed that when the virus carrying IL-7 and IL-12 was injected into tumors, the environment surrounding the cancer became inflammatory. Tumor growth was subsequently inhibited by 93% in melanoma and 53% in colon and lung cancers."