Not sure if this has been shared yet, but I found BIT225 mentioned in the following recent study, on page 4:
Studies on SARS-CoV-1 demonstrated that the E protein uses the IC and PBM to trigger a cytokine storm that activates the inflammasome, leading to increased edema in lungs. Ultimately these events result in ARDS, a leading cause of death in SARS-CoV-1 and SARS-CoV-2 infection. However,the drugs Amantadine, Hexamethylene amiloride and also BIT225(BIT225 is in clinical trials) completely block the IC activity of SARS-CoV-1 and restrict its reproduction, leading to better survival of the animal host. The PBM enables the E protein to interact with the cellular PDZ domains. Its association with the tandem PDZ domains ofsyntenin activates the MAP kinase p38, triggering the overexpression of inflammatory cytokines. Consequently, inhibition of p38 by SB203580 increases the survival of the host5.
https://www.biorxiv.org/content/10.1101/374793v3
https://www.biorxiv.org/content/10.1101/2020.02.17.952895v2.full.pdf
- Forums
- ASX - By Stock
- BIT
- chart weekly
chart weekly, page-899
-
- There are more pages in this discussion • 867 more messages in this thread...
You’re viewing a single post only. To view the entire thread just sign in or Join Now (FREE)
Featured News
Add BIT (ASX) to my watchlist
(20min delay)
|
|||||
Last
1.9¢ |
Change
-0.001(5.00%) |
Mkt cap ! $17.14M |
Open | High | Low | Value | Volume |
1.9¢ | 1.9¢ | 1.9¢ | $5.671K | 298.4K |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
3 | 512798 | 1.9¢ |
Sellers (Offers)
Price($) | Vol. | No. |
---|---|---|
2.0¢ | 1050263 | 5 |
View Market Depth
No. | Vol. | Price($) |
---|---|---|
3 | 512798 | 0.019 |
10 | 1774771 | 0.018 |
8 | 927388 | 0.017 |
12 | 3258350 | 0.016 |
7 | 865000 | 0.015 |
Price($) | Vol. | No. |
---|---|---|
0.020 | 1000263 | 4 |
0.021 | 555000 | 2 |
0.022 | 997769 | 4 |
0.023 | 1100772 | 2 |
0.024 | 153949 | 2 |
Last trade - 15.59pm 04/10/2024 (20 minute delay) ? |
Featured News
BIT (ASX) Chart |