BIT

4.76%

2.0¢ biotron limited

Ann: Biotron to Test its Compounds Against Coronavirus, page-702

First 702 Last

Share
Profile

Follow
J8

14,600 Posts.

832

14/04/20

21:49

Post #: 44041852
Share

Originally posted by malmanu ↑

Its looking less likely existing Biotron compounds or new compounds found will play a role in a treatment imo. No one but Biotron is seeing the E protein as a target.

https://www.nature.com/articles/s41586-020-2223-y

Abstract

A new coronavirus (CoV) identified as COVID-19 virus is the etiological agent responsible for the 2019-2020 viral pneumonia outbreak that commenced in Wuhan1–4. Currently there are no targeted therapeutics and effective treatment options remain very limited. In order to rapidly discover lead compounds for clinical use, we initiated a program of combined structure-assisted drug design, virtual drug screening and high-throughput screening to identify new drug leads that target the COVID-19 virus main protease (Mpro). Mpro is a key CoV enzyme, which plays a pivotal role in mediating viral replication and transcription, making it an attractive drug target for this virus5,6. Here, we identified a mechanism-based inhibitor, N3, by computer-aided drug design and subsequently determined the crystal structure of COVID-19 virus Mpro in complex with this compound. Next, through a combination of structure-based virtual and high-throughput screening, we assayed over 10,000 compounds including approved drugs, drug candidates in clinical trials, and other pharmacologically active compounds as inhibitors of Mpro. Six of these compounds inhibited Mpro with IC50 values ranging from 0.67 to 21.4 μM. Ebselen also exhibited promising antiviral activity in cell-based assays. Our results demonstrate the efficacy of this screening strategy, which can lead to the rapid discovery of drug leads with clinical potential in response to new infectious diseases for which no specific drugs or vaccines are available

Expand

So instead of showing me the quotation that I asked for twice, you come up with something else??

What about all the papers that we’ve posted up here ???? You are cherry picking. Full of it.

BIT Price at posting: 10.5¢ Sentiment: None Disclosure: Held
5 Upvote

0 Great analysis

Reply

Top Stories

MIN

Movers and Shakers: Zip Co, MinRes, Kuniko, more – The week's top ASX gainers

MKT

The ASX can overlook its Telecomm small-caps. Here’s one diversified brand with an international footprint

Bitcoin hits fresh record as instos pile into BTC ETFs – and Trump helps, too

Palladium's the newest geopolitical hot commodity. But ASX exposure is limited

Making money: How many microcaps should be in an investor's portfolio?

Aussie inflation seemingly hit a 3 year low. So why's the ASX200 red?

DXB

Dimerix links up with US NEPTUNE network to boost recruitment for FSGS study

Week 44 Wrap: Relatively boring week ahead of US election; HotCopper's most watched; Oz inflation at 3.5%

'We're looking': Nickel-rich Indonesia sounds graphite warning to Aus producers

The Altcoin Landscape (Part 1): Key alternative cryptocurrencies to watch

There are more pages in this discussion • 356 more messages in this thread...

First 702 Last

Add BIT (ASX) to my watchlist

(20min delay)
Last 2.0¢		Change -0.001(4.76%)		Mkt cap ! $18.04M

Open	High	Low	Value	Volume
2.1¢	2.1¢	2.0¢	$12.00K	600.2K

Buyers (Bids)

No.	Vol.	Price($)
5	972631	1.9¢

Sellers (Offers)

Price($)	Vol.	No.
2.1¢	199783	1

View Market Depth

No.	Vol.	Price($)
5	972631	0.019
10	2364942	0.018
6	738000	0.017
11	1456225	0.016
4	635000	0.015

Price($)	Vol.	No.
0.021	199783	1
0.022	41868	2
0.023	506413	1
0.024	222185	3
0.025	600000	3

Last trade - 14.33pm 01/11/2024 (20 minute delay)

BIT (ASX) Chart

Ann: Biotron to Test its Compounds Against Coronavirus, page-702

Movers and Shakers: Zip Co, MinRes, Kuniko, more – The week's top ASX gainers

The ASX can overlook its Telecomm small-caps. Here’s one diversified brand with an international footprint

Bitcoin hits fresh record as instos pile into BTC ETFs – and Trump helps, too

Palladium's the newest geopolitical hot commodity. But ASX exposure is limited

Making money: How many microcaps should be in an investor's portfolio?

Aussie inflation seemingly hit a 3 year low. So why's the ASX200 red?

Dimerix links up with US NEPTUNE network to boost recruitment for FSGS study

Week 44 Wrap: Relatively boring week ahead of US election; HotCopper's most watched; Oz inflation at 3.5%

'We're looking': Nickel-rich Indonesia sounds graphite warning to Aus producers

The Altcoin Landscape (Part 1): Key alternative cryptocurrencies to watch

Featured News

Buyers (Bids)

Sellers (Offers)

Featured News

Ann: Biotron to Test its Compounds Against Coronavirus, page-702

Top Stories

Movers and Shakers: Zip Co, MinRes, Kuniko, more – The week's top ASX gainers

The ASX can overlook its Telecomm small-caps. Here’s one diversified brand with an international footprint

Bitcoin hits fresh record as instos pile into BTC ETFs – and Trump helps, too

Palladium's the newest geopolitical hot commodity. But ASX exposure is limited

Making money: How many microcaps should be in an investor's portfolio?

Aussie inflation seemingly hit a 3 year low. So why's the ASX200 red?

Dimerix links up with US NEPTUNE network to boost recruitment for FSGS study

Week 44 Wrap: Relatively boring week ahead of US election; HotCopper's most watched; Oz inflation at 3.5%

'We're looking': Nickel-rich Indonesia sounds graphite warning to Aus producers

The Altcoin Landscape (Part 1): Key alternative cryptocurrencies to watch

Featured News

Buyers (Bids)

Sellers (Offers)

Featured News