Thanks for posting the trial dave sss - it gives some idea of the time to be expected for the earliest possible trial termination at the first of 3 interim analyses. ie. "...three interim analyses for stopping accrual early for efficacy and futility when 30%, 45% and 60% of the 300 patients have reached the primary endpoint using Bayesian predictive probabilities."
So when at least 100 patients are available for assessment for "...Number of all-cause mortality within 30 days of randomization."
"...Bayesian predictive probabilities can be used for interim monitoring of clinical trials to estimate the probability of observing a statistically significant treatment effect if the trial were to continue to its predefined maximum sample size...."
So the first interim analysis will hopefully be released in first 2 weeks of June and if they align with the original results, the trial will end.
I wonder what cut-off percentage will trigger the NIH to recommend full Remestemcel-L backing and deployment as recommended treatment for moderate-severe Covid-19 ARDS?
Apologies for repetition or repeat of basics - I'm noob and so doing think out loud noob research.
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