My understanding is animal trials are pre phase 1 and used to prove safety for use in humans. phase 1 is first in human trial and is purely to test safety and toxicity. Generally healthy patients tested. That was why i was curious as i believe we will have no idea of the true effect in symptomatic humans until phase 2. Obviously we have lab indications effect is good but until a human says yes i can see better with no side effects i guess we dont truly know.
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