I hear what you are saying @imback but where I struggle with 'recruitment' is the fact that the California group of hospitals claimed that they had enrolled 30 patients in the trial (10%) in less than two months through Dr Bowdish blog that was later removed. While we weren't supposed to know this information obviously - we now do .... hehe
The following hospital groups (see link) were all added to the clinical trials website on 1 May 2020 (6 in total) the same day along with the California group - you would assume they were all brought online / up to speed around the same time ? Therefore that would only need the other 5 hospital groups to recruit 12 participants in two months to get to the initial 90 people - a little over one a week. That excludes any new hospital groups brought on after this date so I am hoping we are more advanced than most think - but just my musings while we wait
I figure we are well past half way by now and we could see full recruitment before the interim analysis is undertaken ... I think all parties would prefer 100% recruitment to ensure there is in fact 'robust' data ... I also believe now that the death numbers are again on the rise in the USA that whatever residual is required to fulfill 100% recruitment, it will happen well and truly prior to the end of August.... I guess we will see as the month progresses ?
2. Severely sick people on ventilators aren't probably in the best frame of mind to make a decision to be part of a novice trial; so I'd assume their next of kin have to make the decision on their behalf. That decision is going to be a hard one.
Nice points raised in your post but I respectfully disagree with this comment as I believe that patients receive SOC regardless of the participation in the trial or not ... I know if given the choice to enroll my loved one in this trial (even with a 50% chance of receiving placebo) I would jump at it as I believe they really have nothing to lose and a 50% chance of everything to gain - but then again I have read all the reports
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... I also believe now that the death numbers are again on the rise in the USA that whatever residual is required to fulfill 100% recruitment, it will happen well and truly prior to the end of August.... I guess we will see as the month progresses ?
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