The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection
https://www.sciencedirect.com/science/article/pii/S0091674920309593
A hyperinflammatory state referred to as cytokine storm in its severest form has been marked by elevation of IL-6, IL-10, TNF-α, and other cytokines and severe CD4+ and CD8+ T-cell lymphopenia and coagulopathy. Recognition of at-risk patients could permit early institution of aggressive intensive care and antiviral and immune treatment to reduce the complications related to this proinflammatory state. Several reports and ongoing clinical trials provide hope that available immunomodulatory therapies could have therapeutic potential in these severe cases. Currently, studies examining the combination of direct antiviral agents with immunomodulatory therapy are ongoing and will be important in the quest to prevent acute respiratory deterioration, ventilation use, morbidity, and mortality from SARS-CoV-2 infection.
Whilst we are all waiting in anticipation of a positive announcement, here is some light reading (actually its a long read) that discusses the cytokine storm, CD4 & CD8 T-Cell, pretty much describing BIT without mentioning it by name, ideally we will soon have a post (or series of posts and papers) that will feature BIT as the solution we have all been waiting for. Good Luck all.
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