Whoa whoa whoa... are you saying that even with the methylated and unmethylated it’s “not yet possible to quantify the potential treatment advantage of GDC-0084 vs. temzolomide”.
Do some research before posting if that is your actual point of view! Perhaps you would care what you posted if you had skin in the game
DYOR: How beneficial is temzolomide in unmethylated glioblastoma?
Check out Hegi, M.E., et al., MGMT gene silencing and benefit from temzolomide in Glioblastoma.
-You will find only marginal benefit of 12.7 vs 11.8 for ChemoRT vs. RT alone. Sooo we need a drug that works better in the unmethylated group at the very least as temzolomide does almost nothing in the unmethylated.