So out of 450 newly diagnosed cases 225 got treated and 4 ended in hospital. Out of other 225 13 ended in hospital. Difference of 7 could be due to many other things and may be there is no change.
If 1-2 out of 100 case end up in hospital then chances are that you may take a random sample of say 153 and no body goes to hospital. May be you take a sample of another 50 and 30 are from aged care then chances are 15-20 will end up in hospital. When dealing with small percentages the trial size should be bigger. You only need to look at how vaccines are tested and something similar should apply with this one.
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