The numbers in your post are placebo-adjusted which is calculated as reduction under DMX200 minus reduction under placebo
"
26 patients with an average reduction of 18%
14 patients with an average of x
40 total patients with an average reduction of 2%
"
The 25% increase reflects placebo has better result than the drug. One possible reason is legacy effect.
Ann: Positive Top-Line Results in DKD Phase 2 Clinical Study, page-336
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