Again, CYP does not need 3D so I don't get why you are asking about CYP doing something that they're not doing.
Re your question, we are not the FDA, we don't decide to what extent variation in manufacture to that approved process is acceptable. So will the FDA make MSB do additional trials if they alter their manufacturing process by introducing 3D? how is anybody here supposed to know what the FDA will decide? is it a risk that the FDA will require some additional trials or tests? Yes. But only the FDA will know what they will require.
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