Ann: TPM Cannabinoid Development Program Update, page-109

Folks AVE have already missed the CBD Train and don't have any Patent Protection, in fact IMHO they may infringe Patents. (DOYR)

There are companies already out there that have lodged Patent applications for TPGS (same as TPM*) and CBD

Patent Announcement from last Sept to by MCTC (who are listed on NASDAQ)

MCTC - Achieves Sub-Micron Polymeric Particles of Cannabidiol (CBD) and TPGS (same as TPM*) - Files Cannabinoid Nanoparticle Patent

NASDAQ Announcement Sept 2019 Link here: https://www.nasdaq.com/press-release/mctc-achieves-sub-micron-polymeric-particles-of-cannabidiol-cbd-and-tpgs-files-0

From the ANTARES site -Vitamin E TPGS (*same as TPM), a derivative of naturally sourced alpha-tocopherol is becoming the formulation ingredient of choice for cannabis products, especially purified or concentrated CBD and THC and other extracts.

TPGS has:
• A proven record of safety (1,5) based on decades of commercial use in pharmaceuticals and dietary supplements, including vitamin formulations for children.

• Efficacy based on conclusive clinical evidence (6), not only as a solubilizer for water soluble formulations, but also in its ability to form micelle like particles that enhance absorption and bioavailability. Its efficacy is illustrated by its use in clinically-tested (7), FDA approved products formulated for enhanced absorption.

• Neutral taste and odor and light yellow color are particularly important for oral and personal care product formulations.

• Support of product stability. Vitamin E TPGS contains some free tocopherols that have strong antioxidant activity and support product stability especially for oil-based products. In addition to reducing potency, products of oxidation affect taste, odor, and can be harmful.

Further please note that given the statements from the AVE CEO, this technology needs to go through Phase 1,2,3 trials, so to put that into perspective less than 5% of drugs put up for FDA Approval actually get through after a couple of hundred million dollars (which AVE dont have ) and about 7 years in a timeline

Forget CBD and TPM its fairy dust IMHO

* Same as TPM in this particular use