Agreed ... but it is is far from common-sense to understand conceptually why in a P3 confirmatory trial you have a hierarchical structure of outcomes. And when the primary outcome fails statistical significance on your secondary outcomes is meaningless.
You would have to write a book to explain why this is so.
But on your second point about a terrible choice of outcomes … I would disagree agree slightly. The outcomes for CHF and LBP were not bad per se. Rather it was the process that generated them which was flawed. So I agree with dplanes point about overconfidence on weak P2 results.
The trouble is running P3 trials as if they were exploratory P2 trials – to learn as you go and to generate interesting sub-group efficacy signals on different endpoints for later testing in ……more P3 trials is completely un-viable.
- Forums
- ASX - By Stock
- MSB
- Ann: Mesoblast Phase 3 Chronic Low Back Pain Results
Ann: Mesoblast Phase 3 Chronic Low Back Pain Results, page-290
-
- There are more pages in this discussion • 814 more messages in this thread...
You’re viewing a single post only. To view the entire thread just sign in or Join Now (FREE)
Featured News
Add MSB (ASX) to my watchlist
|
|||||
Last
98.0¢ |
Change
-0.015(1.51%) |
Mkt cap ! $1.124B |
Open | High | Low | Value | Volume |
$1.00 | $1.01 | 97.5¢ | $603.7K | 611.4K |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
8 | 70462 | 97.5¢ |
Sellers (Offers)
Price($) | Vol. | No. |
---|---|---|
98.0¢ | 58370 | 30 |
View Market Depth
No. | Vol. | Price($) |
---|---|---|
9 | 73555 | 0.975 |
15 | 201572 | 0.970 |
12 | 131422 | 0.965 |
10 | 149862 | 0.960 |
3 | 17966 | 0.955 |
Price($) | Vol. | No. |
---|---|---|
0.980 | 44211 | 28 |
0.985 | 46753 | 14 |
0.990 | 64387 | 29 |
0.995 | 57668 | 4 |
1.000 | 71548 | 7 |
Last trade - 11.19am 20/08/2024 (20 minute delay) ? |
Featured News
MSB (ASX) Chart |