MSB 7.69% $1.19 mesoblast limited

Ann: Remestemcel-L for COVID-19 MIS-C published in Pediatrics, page-66

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    You mentioned hypertensives and steroids can cause hypertension. Children initial days in hospitalisation, both children received SOC which included steroids.

    They observed abnormal cardiac dysfunction/injury. Like, deceased LV function/need for inotropes, elevated levels BNP (as you mentioned), systemic/cardiac/endothelial inflammation (elevated levels of C-reactive protein) and others. (all in article)

    Thus, remestemcel_l was considered.

    You inquired when in the day the children go treated? Patient one was treated in hospital day 5 & 7 and Patient 2 hospital days 3 & 5.

    The article did state neither child experienced any adverse effects associated with remestemcel_L administration. I mentioned this because your comment; profound hypertension is absolutely something they glossed over as well, and it's funny they say there's no adverse effects and go on to mention one kid is still on antihypertensives.

    Yes both children developed rebound hypertension, together with anaemia, and both children continued to show clinical and laboratory improvements by discharge day.

    Both children showed rapid normalisation of their LV ejection fraction and B-type natriuretic protein as well as improvement in D-dimer.

    Data suggest that rem_L contributed to further improvements in myocardial and endothelial function and promoted additional reductions in systemic and cardiac inflammation.

    The data was positive in relation to heart, which bides well with CHF results. Also, i would like to mention, yes High BNP levels are less conclusive but in patients with suspected CHF in 50 to 75 year olds, in older patients support the diagnosis up to 90%.

    We need to tell the whole story not part off.

 
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