Ann: Immutep expands Part B of TACTI-002 collaboration trial, page-15

You are right Joe - Step change in business could also be:-
The world of Step-Change, which (author - Kishner) define as achieving massive increases in performance that look like “steps” when depicted on a graph. Step-change requires a completely different mindset than Incremental Change, which looks like a gentle linear slope when depicted on a graph.
The $2 billion question is exactly what does 'step change' mean for Immutep?
R&D companies are typically incremental due to length of time of clinical trials. That is until a binary event(s) - and then the big step.
Major licensing deal or partnership or complete take-out by big pharma?....It certainly is not 'business as usual' later this year - something is brewing behind the scenes, Marc has mentioned 'step change' several times recently, which has not been part of his vocabulary previously.