Pillar 1 - FTO (new thread), page-485

The mention of weight gain reminded me of a pile of links I had when I first did a bit of research on what an FTO is, I didn't bother putting it up here because I guess we're taking the FTO/cause as a bit of a given and looking at the efficacy of Bisantrene itself, but it definitely put my mind at ease that if Bisantrene did what we hope it will then we're on to something big...

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion
...FTO inhibition sensitizes leukemia cells to T cell cytotoxicity and overcomes hypomethylating agent-induced immune evasion...

Novel positioning from obesity to cancer: FTO, an m6A RNA demethylase, regulates tumour progression
...FTO not only plays a critical role in obesity-related diseases but also is involved in the occurrence, development and prognosis of many types of cancer, such as acute myeloid leukaemia, glioblastoma and breast cancer....

Critical Enzymatic Functions of FTO in Obesity and Cancer
...Given the critical roles of FTO in cancers, the development of selective and effective inhibitors targeting FTO holds potential to treat cancers....

Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer
...Aberrant expression of demethylase genes, FTO and ALKBH1, has a distinct prognostic value in GC patients, indicating that FTO and ALKBH1 may play vital roles in GC progression and metastasis....

The role of the fat mass and obesity associated gene (FTO) in breast cancer risk
...In conclusion we have shown a significant expression of FTO in malignant and normal breast tissue and that FTO SNPs in intron 1 are significantly associated with breast cancer risk....

Single nucleotide polymorphisms of the FTO gene and cancer risk: an overview
...However, it is now unquestionable that certain FTO polymorphisms regulate genetic expression related to cancer susceptibility, although this field is just beginning to be understood...

FTO Gene Affects Obesity and Breast Cancer Through Similar Mechanisms: A New Insight into the Molecular Therapeutic Targets
...Over expression of the FTO gene increases the levels of mammalian target of rapamycin (mTOR) signaling that is a key regulator of cell growth....

FTO expression is associated with the occurrence of gastric cancer and prognosis
...It has been reported previously that FTO is associated with a variety of malignant cancers, such as breast, thyroid and endometrial cancer. The aim of the present study was investigate the FTO expression of human gastric cancer and to investigate its clinical value....