The principles and phenomena from materials research to study the structure of liquid water and its relevance to homeopathy were discussed. Liquid water is a nanoheterogenous statistical-mechanical distribution mainly of several molecular species including oligomers and polymers along with a minority of monomers. The structure can be easily affected by epitaxial effects, pressure during succussion, the formation of colloidal nanobubbles, and electric and magnetic fields. In homeopathy a specific active agent is added to the liquid (water or water + ethanol). The change in the internalized model is a de-emphasis on the precise possible molecules into which water may polymerize.