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  1. Bylosellhi
    247 Posts.
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    31/03/21
    14:45
    Post #: 52175616

    From earlier this month
    LAG3 and its emerging role in cancer immunotherapy

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989707/
    There are two types of LAG3‐targeting agents used as antitumor immunotherapies: LAG3 soluble dimeric recombinant protein named IMP321 and LAG3 mAb Or IMP321 v antibody universe.
    Lines are being drawn for the scientific showdown in cancer immunotherapy. Stay tuned for the latest results.

    TABLE 1Clinical studies of LAG3 single‐targeted immunotherapy

    DrugsNCT IDTumor typesPhaseNumber enrolledCombination agents (targeting LAG3 drugs + X)Status
    Soluble LAG3 Ig
    IMP321NCT03252938Solid tumorsI50AvelumabRecruiting

    		NCT03625323NSCLC, SCCHNII109PembrolizumabRecruiting

    		NCT00351949Advanced RCCI24–Completed

    		NCT02676869Stage III/IV melanomaI24PembrolizumabCompleted

    		NCT02614833Adenocarcinoma breast stage IVII241PaclitaxelActive, not recruiting

    		NCT00349934Metastatic breast cancerI33PaclitaxelCompleted
    Anti‐LAG3 mAb

    BMS986016

    Relatlimab

    		NCT02966548Advanced solid tumorsI45NivolumabActive, not recruiting

    		NCT02061761Hematologic neoplasmsI/II109NivolumabActive, not recruiting

    		NCT03743766MelanomaII42NivolumabRecruiting

    		NCT01968109Neoplasms by siteI/II1500Nivolumab, BMS‐986213Recruiting

    		NCT03623854ChordomaII20NivolumabRecruiting

    		NCT03493932GlioblastomaI25NivolumabRecruiting

    		NCT03642067Colorectal adenocarcinomaII64NivolumabRecruiting

    		NCT03459222Advanced cancerI/II230Nivolumab, Ipilimumab, BMS986205Recruiting

    		NCT04326257SCCHNII40Nivolumab, IpilimumabRecruiting

    		NCT03607890Refractory MSI ‐ H solid tumors prior of PD‐L1 therapyII21NivolumabRecruiting

    		NCT02488759Advanced cancerI/II584Nivolumab, Ipilimumab, DaratumumabActive, not recruiting

    		NCT02658981GliosarcomaI100NivolumabRecruiting

    		NCT02996110Advanced cancerII200Nivolumab, IpilimumabRecruiting

    		NCT02750514Advanced cancerII504Dasatinib, NivolumabActive, not recruiting

    		NCT02060188Microsatellite unstable colorectal cancerII340Nivolumab, Ipilimumab, CobimetinibRecruiting

    		NCT04080804SCCHNII60Nivolumab, IpilimumabRecruiting

    		NCT02935634Advanced gastric cancerII600Nivolumab, IpilimumabRecruiting

    		NCT02519322Cutaneous melanomaII53Nivolumab, IpilimumabRecruiting

    		NCT03044613Gastric cancerI25Carboplatin, NivolumabRecruiting

    		NCT04062656Gastric cancerII88Nivolumab, IpilimumabRecruiting

    		NCT03335540Advanced cancerI50Cabiralizumab, NivolumabRecruiting
    LAG525NCT03499899Triple negative breast cancerII88SpartalizumabActive, not recruiting

    		NCT03365791Advanced solid and hematologic malignanciesII76PDR001Active, not ecruiting
    IMM Price at posting: 40.5¢ Sentiment: Buy Disclosure: Held
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    lightbulb Created with Sketch.  Great analysis
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