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Ann: PTX-200 AML Trial Progresses to Higher Dose, page-27

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psych101

1,656 Posts.

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24/04/21

21:24

Post #: 52702287
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Originally posted by rlj: ↑

"The other possibility is that they have a crap writer, and the word "the" should not have been included. If you delete it, then it would be reasonable to assume that the three patients at 35gm were new patients."

I would suggest that this is the case and that is a Single Ascending Dose trial where three different patients each receive one dose, as the next paragraph of the announcement goes on to read

"Following review of the safety data from this cohort with the study investigators, Prescient has opened the next cohort for enrolment at 45 mg/m2 PTX-200."

Which suggests that they are now searching for the next three different patients who have yet to receive the drug.

https://www.nuventra.com/services/pharmacokinetics-pharmacodynamics/multiple-ascending-dose-studies/

Expand

Tend to agree rlj, re ascending or escalating dosage to controlled cohorts ( 3x3x3). Besides Davey’s observation re ‘poor use of grammar’ option, the question remains why up the dose ( outside design of course) when your efficacy is optimal- 3 CRs ( complete responses out of 3 participants.
Hope the quarterly clarifies further.

Last edited by psych101: 24/04/21

PTX Price at posting: 9.4¢ Sentiment: Buy Disclosure: Held
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