Because the r/r AML patients have exhausted all treatment options the only way you could run a double blind trial is to run a placebo as the comparator arm. Untreated all AML patients die - commonly within a few weeks.
In practice it wouldn’t be possible to run a double blind study anyway given that Bisantrene is fluro orange and makes your urine fluro orange too.
Ann: Race Strategic Update March 2021, page-512
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