Luck. Bisantrene was always of some interest with its lack of cardiotoxicity as a chemo agent, but in the middle of last year it was discovered by a team out of the City of Hope in Los Angels that Bisantrene is also a very potent inhibitor of the FTO protein. FTO has recently been discovered to be important is a huge number of cancers (basically all) and also to overcome treatment resistance to a huge range of cancer treatments. Bisantrene has gone from being a bit of niche drug targeting AML, to be centre stage in the hottest area of oncology today.
Medical / Clinical Discussions, page-468
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