I missed the eye papers by Sinclair and in fact, he has 2 papers published last year. We do not know if ATH434 will activate Sirtuins but that is what I believe is happening. IMO, without sirtuin activation, the animal studies would not demonstrate so good results as we have seen in the 2 ATH434 papers published, most clearly the paper by Stefanova et al last July in the MSA animal model. As you may remember sirtuin activation needs NAD+. In the first paper below NAD+ precursor, NMN demonstrated a neuroprotective effect.
Here are the 2 papers by Sinclair et al.
Aging | Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment - Full Text (aging-us.com)
Reprogramming to recover youthful epigenetic information and restore vision | Nature
Experimental method to study macula degeneration, page-3
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