I know a few people who have tried Psylocybin and they have said that it is has been an extraordinary positive for their mental health. Having a therapeutic environment and protocol is IMO mandatory.
What is interesting is that we are taking natural substances like mushrooms (dating back 700 million years ago) and Cannabis (fossils dating back 20 million years) that have evolved optimally and combining them with synergistic newer technologies/therapies for a revolution in medicine. The Endocannabinoid system in primitive animals evolved 600 million years ago. It is no surprise that we are seeing success in these therapies - the biologic framework is there.
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