Ann: Quarterly Activities/Appendix 4C Cash Flow Report, page-8

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EP3928763 - Transmucosal and Transdermal Delivery Systems
https://patentscope.wipo.int/search/en/detail.jsf?docId=EP346690303

Field of the Art

[0001]  The present invention relates generally to transmucosal (typically oral and/or nasal) and transdermal delivery systems and methods for making such delivery systems.

Background

[0002]  Oral formulations for the delivery of vitamins, minerals and active pharmaceutical ingredients include tablets, capsules (hard and soft shelled), lozenges, powders, emulsions and liquids. In order to benefit from such formulations and ensure optimum absorption of the vitamins, minerals or active pharmaceutical ingredients the subject must have a well functioning gastrointestinal system that ensures adequate absorption via the gastrointestinal tract. Not all subjects have a well functioning gastrointestinal system and therefore can not make use of such oral formulations. It is therefore beneficial to produce formulations that can be absorbed transdermally or via the oral and/or nasal mucosa, for example via the highly vascularized oral-buccal mucosa, such that the vitamins, minerals or active pharmaceutical ingredients are provided direct access to the body's systemic circulation system via capillaries thereby bypassing the gastrointestinal tract.

[0003]  Many active pharmaceutical ingredients, for example insulin, are typically administered via needle and syringe, and the like such as pens, jet injectors and pumps. Many people find such administration devices to be daunting, uncomfortable and generally inconvenient. It is therefore beneficial to produce formulations that can be absorbed via the oral and/or nasal mucosa, for example via the highly vascularized buccal/sublingual mucosa, such that the insulin is provided direct access to the body's systemic circulation system via capillaries thereby avoiding the need to break the skin.

[0004]  The present inventors have found that transdermal and transmucosal (oral and/or nasal) delivery systems comprising at least one non-ionic surfactant; at least one polyol; and at least one active agent can be successfully administered bypassing the gastrointestinal tract and avoiding the need to break the skin.