Tumor Immune Microenvironment of Brain Metastases: Toward Unlocking Antitumor Immunity

CANCER DISCOVERY
Absract - aacrjournals.
Tumor Immune Microenvironment of Brain Metastases: Toward Unlocking Antitumor Immunity Matthew R. Strickland ; Christopher Alvarez-Breckenridge ; Justin F. Gainor; Priscilla K. Brastianos
Review - April 08 2022

"Figure 5.  Role of microglia and bone marrow–derived macrophages in BrM..
6. BrM have been shown to have enriched PI3K signaling activity and that PI3K is a master regulator of
metastasis-promoting microglia/macrophages. PI3K is an attractive therapeutic target with a growing list of CNS-penetrant inhibitors available such as GDC-0084".

https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-21-0976/694321/Tumor-Immune-Microenvironment-of-Brain-Metastases#.YlKuYdo4cDU.twitter

Data news from Priscilla K. Brastianos regarding paxalisib (GDC-0084) has been limited for some time.
Open the link and download the PDF for full details of the abstract.

Note: Initial interim data from paxalisib phase II brain metastases study with Alliance for Clinical Trials in Oncology 1H CY2022

Regards.