lani results out

DS have proved efficacy against H274Y tami resistant swine flu - It was probably a given - but something that needed proving under the current circumstances(another obstacle cleared)

Antimicrob Agents Chemother. 2010 Jan 4. [Epub ahead of print]
CS-8958 ( laninamivir prodrug), a long-acting neuraminidase inhibitor, shows superior
anti-influenza virus activity after a single administration.
Kubo S, Tomozawa T, Kakuta M, Tokumitsu A, Yamashita M.
Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd., 1-2-58, Hiromachi, Shinagawa, Tokyo 140-8710, Japan.
... CS-8958 administered just once 7 days before infection showed significant efficacy in vivo. {mice ?}
Then, the efficacy by a single administration of CS-8958 after viral infection was compared with
that by repeated administrations of oseltamivir phosphate or zanamivir in mice and ferrets
and CS-8958 showed superior or similar efficacy to the two licensed NA inhibitors.
CS-8958 also significantly reduced the virus titers of an oseltamivir-resistant H1N1 virus with a neuraminidase H274Y substitution in a mouse infection model.
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