Edski et al.
Some good discussion here so far...yes it makes sense that the placebo effect can also go the other way, ie in a double blinded trial you may think you aren't getting the real drug and this would possibly balance out to some effect.
Here were some other interesting points I came across regarding Placebo:
That second bullet point was interesting, placebo effect can work in some cases even if the patient is sceptical.
Agree with you that we may possibly need to make a distinction between pill format and subQ, specially at a Doc (and Medical association level).
IC still affects a few million patients which is a fairly high number.
Our eventual data and the great results (my views) from P3 will do a lot of the talking too.
Good to get your thoughts.
Ref
https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/placebo-effect
https://www.niddk.nih.gov/health-information/urologic-diseases/interstitial-cystitis-painful-bladder-syndrome/definition-facts#:~:text=IC%20is%20common.,men%20in%20the%20United%20States.
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