CYP cynata therapeutics limited

Cymerus MSCs for Neonatal Stroke, page-8

  1. 1,304 Posts.
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    You wrote, "Obviously the plan did not go well."
    Care to share what makes you think that the plan did not go well?


    I also noticed your comment about our "mob" 's P1 trial over on the other thread:
    https://hotcopper.com.au/data/attachments/4682/4682559-ae0305a563b992af393447c0c24c7e18.jpg
    https://hotcopper.com.au/threads/banter-and-general-discussion.5410558/page-4718?post_id=63726744

    Any chance you could provide a link that shows a comment about Cohort B showing a clinical response on day 3?

    I can see that participants had a study visit on day 3 according to the trial design:

    https://hotcopper.com.au/data/attachments/4682/4682575-252aa81fea2baee5f59b52ac378a51a9.jpg
    https://clinicaltrials.gov/ct2/show/NCT02923375

    But I can't see any mention of data being collected and/or presented for that timepoint later on.


    Your post also mentions, "What did your boss say about why they would go for the high dose?"
    https://hotcopper.com.au/threads/banter-and-general-discussion.5410558/page-4724?post_id=63727240

    I know what Kilian Kelly said:

    https://hotcopper.com.au/data/attachments/4682/4682623-e80a362d7618e6d3c9477419f0670471.jpg
    https://app.sharelinktechnologies.com/announcement/asx/176993991ab6cb44f055a76242029f9d

    This is an observation that is in line with Galiepau's findings:

    https://hotcopper.com.au/data/attachments/4682/4682642-9bfb6a13f31882e337155b33ed19684a.jpg
    https://www.cell.com/cell-stem-cell/pdfExtended/S1934-5909(18)30222-4

    It therefore makes sense to use the higher dose which showed a "much quicker treatment response" early on. However, having data as early as day 3 would be very interesting to see as it would allow us to break down the provided data even further, even more than the published article in Nature has done.
    https://www.nature.com/articles/s41591-020-1050-x
 
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